Niacin without a flush has the ability to widen blood vessels and has been used to treat conditions such as Raynaud's disease. Experiments using nicotinic acid abound; however, investigations on the efficacy of inositol hexaniacinate alone in decreasing cholesterol levels are scarce. Still, studies have shown that supplementing with inositol can help reduce symptoms of depression and anxiety, improve memory, and promote heart health.
Why is it called niacin flush-free? Because the ingredient in question is inositol hexaniacinate, which has been found not to cause any flushing when taken by itself. However, when taken with vitamin B3 (also known as niacin), inositol hexaniacinate will remove the flush caused by niacin.
Does this mean I shouldn't take niacin if I'm black? No, but there may be other reasons why you wouldn't want to take it. Your doctor should know all your medical history before prescribing medications or other treatments.
Importance Although niacin remains a treatment option for people with cardiovascular disease, recent research has called into doubt the efficacy of other medicines that raise high-density lipoprotein cholesterol levels.
Niacin is one of only two drugs approved by the U.S. Food and Drug Administration to increase levels of high-density lipoprotein (HDL) cholesterol. It works by raising HDL cholesterol while reducing low-density lipoprotein (LDL) cholesterol and triglycerides. Increases in HDL cholesterol may protect people who have heart disease or risk factors for it from further illness and injury. Reductions in LDL cholesterol and triglycerides can help prevent another heart attack or stroke.
People who are at least 18 years old with HDL cholesterol levels below 40 mg/dL (1.03 mmol/L) should be given niacin to boost levels of this protective type of cholesterol.
Those who have not had a heart attack but are at high risk for doing so might benefit from niacin therapy to reduce their risk. Risk factors for heart disease including high blood pressure, diabetes, obesity, smoking, and aging play major roles in determining someone's risk of having a heart attack or dying of a related cause. The more risk factors you have, the higher your overall risk is considered to be.
Flush-free niacin has been linked to an increased risk of liver damage and a reduced ability to control cholesterol. At this stage, it's impossible to establish how its many characteristics affect its ability to pass a drug test. Flush-free niacin is a kind of B3 that is commonly found as inositol hexanicotinate. It may be produced by treating corn or wheat with acid or heat. This process removes most of the starch from the grain which can then be sold as flour for other products. The powder that remains after drying out the starchy material contains mostly niacinamide and small amounts of other substances such as iron, zinc, and phosphorus.
NIACIN (also known as vitamin B3) is one of the nine essential vitamins required for human health. Although found in many foods, including meats, vegetables, and nuts, niacin needs to be taken as a supplement because it is usually destroyed during processing. Dried corn, wheat, and rice all contain significant amounts of niacin. However, when these grains are processed into flour, much of the niacin is lost. Therefore, if you're taking part in a drug test to determine whether you have used drugs such as marijuana, cocaine, heroin, methamphetamines, or painkillers, then there is a good chance that your results will show up positive for niacin.
HOW DOES NIACIN FLUSH FREE WORK? When you consume niacin, it becomes active inside your body quickly.
Finally, niacin can reduce lipoprotein (a) levels by up to 30% while also improving LDL and HDL cholesterol levels. Studies have shown that taking 1-3 grams of niacin daily can help reduce the risk of heart disease by increasing these good cholesterol levels in the blood.
Niacin is one of only two drugs approved by the FDA for lowering low-density lipoprotein (LDL), or "bad," cholesterol. It works by reducing the amount of fat used for fuel by the body, which in turn lowers plasma levels of triglycerides and increases levels of high-density lipoprotein (HDL) cholesterol. Niacin can also increase production of apolipoproteins AI and AII, proteins that aid in the breakdown and removal of lipid particles from the bloodstream. As a result, it has been shown to be effective in reducing the risk of heart attack and stroke.
In addition to its role in lowering cholesterol, niacin has other beneficial effects on the body's lipid profile. Evidence suggests that it may reduce the risk of heart disease by clearing excess clotting factors from the bloodstream, promoting healthy blood flow, and preventing plaque from forming on artery walls.
An good study conducted by experts at the University of Washington School of Medicine revealed that consuming no-flush niacin produces almost little free nicotinic acid and has little or no effect on HDL. Because it does not provide any niacin to the body, no-flush niacin stands up to its name. However, the study also showed that even though no-flush niacin has less absorption, it still can produce beneficial effects for blood cholesterol levels if used in combination with other foods containing natural sources of niacin.
When used in high doses, regular niacin supplements can create a niacin flush, an unpleasant response characterized by a burning feeling and reddening of the skin on your face and joints. Inositol hexanicotinate is less likely to elicit the niacin flush, however it may cause liver damage if used long term. Long-term use of inositol supplements may also cause depression or anxiety. There are no studies showing that supplementing with inositol causes any other problems for most people.
Taking high levels of niacin can be dangerous because it can build up in your body and cause serious problems. If you experience any of the following symptoms while taking niacin, stop taking it immediately: nausea, vomiting, diarrhea, stomach pain, fever, chills, cough, shortness of breath, sore throat, loss of appetite, dark urine, light-colored stools.
If you take more than 500 mg of niacin daily, ask your doctor how much niacin you should be taking. They may want you to limit yourself to 250 mg daily to avoid potential side effects. You should never take more than 2 grams of inositol per day. That's why some brands combine inositol with other ingredients such as vitamin B6 and folic acid to make sure you don't get too much of either one factor.
Nicotinic acid (niacin) is a well-known therapy for dyslipidaemia, a major risk factor for cardiovascular disease (CVD). However, niacin may also lower blood pressure (BP), which is a major risk factor for CVD. In fact, data from several large clinical trials show that treatment with niacin reduces the risk of coronary heart disease (CHD) and stroke by approximately 25%. Furthermore, studies in animals have shown that niacin can reduce atherosclerosis in different parts of the body, including the brain and peripheral limbs.
Lowering blood pressure lowers your risk of having a heart attack or suffering from angina (chest pain). Therefore, taking niacin may also help prevent CHD events other than heart attacks. The mechanism behind its effect on BP is not clear but may be related to reduced production of prostaglandins or increased activity of vasodilators such as nitric oxide. There has been some concern that taking niacin could cause it to be removed too quickly from your system, so it cannot work as effectively. But recent studies have shown that higher doses for longer periods of time are safe and do not affect how your blood cells function over time.
It is not known if other B vitamins play a role in lowering blood pressure, but research does suggest that they can help prevent CHD events.