It may take a few days, or even weeks, for aripiprazole to begin working for you. It is possible that you will not experience the full benefits of the drug for four to six weeks. It's difficult to be precise because aripiprazole acts differently for each individual. Some people start feeling its effects within hours of taking it every day, while for others it could be months before they feel its effects.
Like all medications, there are possibilities for side effects when taking Abilify. These include but are not limited to: nausea, diarrhea, irritability, drowsiness, insomnia, headache, memory problems, anxiety, depression, weight gain or loss, hot flashes, skin reactions, dry mouth, urinary frequency, bladder control issues, sexual dysfunction. Many of these side effects go away after several days or weeks but others may last longer such as memory problems and weight change.
The most common side effect of Abilify is nausea (54 percent of patients), followed by diarrhea (36 percent), headache (34 percent), drowsiness (30 percent), irritability (27 percent), insomnia (26 percent), muscle pain (20 percent), anxiety (19 percent), vomiting (12 percent), and self-reported fever (10 percent).
These percentages include both those who experienced no other side effects and those who did.
The average elimination half-lives of aripiprazole and dehydro-aripiprazole are around 75 and 94 hours, respectively. Both active moieties reach steady-state concentrations within 14 days of treatment. The buildup of aripiprazole is predicted based on single-dose pharmacokinetics. For dehydro-aripiprazole, no dose adjustment is needed for age or body weight.
Aripiprazole remains in your system for about three weeks. It may still be in your system up to 10 months after you stop taking it.
Dehydro-aripiprazole remains in your system for up to 52 days. But because its concentration falls off more slowly, it may still be in your system for up to six months after you stop taking it.
Studies have shown that the benefits from Abilify last for as long as two years. However, there will be times when you will want to continue to feel those benefits beyond this time frame. In these cases, it is important to take your medication as prescribed by your doctor. If you stop taking it, your symptoms might return when you resume treatment.
Some people report dry mouth as one of their side effects when starting Abilify.
This drug will take action fast, within 1 to 2 hours, and clinical symptoms should improve. The effect lasts from 3 to 6 days.
Clorazepate is used to treat anxiety disorders, such as obsessive-compulsive disorder (OCD) and post-traumatic stress disorder (PTSD). It works by blocking the activity of certain cells in the brain that become overactive in anxiety disorders. At low doses, it produces minimal side effects while still providing good relief from symptoms.
In addition to its role in treating anxiety disorders, clorazepate can be used to treat depression, panic attacks, seizures, and other conditions. It may also be used along with other medications to treat these conditions.
Clorazepate comes in tablets that are chewed or swallowed whole. It should not be taken with alcohol or other medications since doing so may cause adverse effects. Clorazepate is believed to be safe during pregnancy but has not been studied extensively. If you are pregnant or plan on becoming pregnant, talk to your doctor about alternatives that are considered safer for you and your baby.
Aripiprazole is primarily removed by metabolism via the cytochrome P450 (CYP) enzyme system, while dehydro-aripiprazole is eliminated mainly through urine.
The drug's plasma protein binding is greater than 99%. It is distributed widely throughout body tissues. Around 70% of the drug is bound to human serum albumin. The presence of abilify in blood cells is known but has not been reported to affect how the drug works.
Abilify carries warnings for patients who take it every day because it can cause dry mouth and irritability. Patients should also be cautioned about driving or operating machinery when taking this medication due to its sedating effects.
Abilify remains active even after it has been cleared from your body. This means that it can still provide benefits even if you stop taking the drug all at once or in increments over time.
Experts advise against stopping taking abilify all at once or in increments unless directed to do so by your doctor. Doing so may lead to a return of symptoms that caused you to begin taking the drug in the first place.