Intravenously, edrophonium chloride Tensilon (r) is a short-acting medication. If your weakness, particularly in the eye muscles, improves momentarily and temporarily, you may have MG. If this effect occurs quickly, within minutes, of injecting edrophonium into your vein, it is called a "positive twitch test." This means that you have myasthenia gravis.
If you do not show any improvement in your muscle strength or feel any side effects from the drug, this means that you do not have MG. The test cannot tell whether you are truly weak because you are trying to be nice or if you really are unable to move some muscles due to other problems, such as multiple sclerosis or muscular dystrophy. The test can only diagnose you with myasthenia gravis; it cannot cure you of this disease.
Edrophonium testing is used to help doctors choose the right treatment for you. It may also be useful in monitoring your response to therapy. Tensilons are injected into a large vein in your arm or leg.
Myasthenia Gravis is a disease in which the body's immune system attacks the nerves that control movement. The result is weakness of the face, neck, arms, legs, and trunk.
Because some people are particularly sensitive to even modest concentrations, a 2-mg (0.2-mL) test dose of edrophonium is provided. If no improvement is seen after 30 seconds, the remaining 8 mg is given in modest increments (2 mg every 15 seconds). The test should be repeated every 4 hours until either a positive response is seen or 48 doses have been administered.
The average total daily dose for an adult is 16 mg, divided into four injections. Higher doses may be required in severe cases.
The drug has no effect on healthy people, but it can be used as a test to determine whether someone is allergic to aminoglycosides. If you are allergic to any other drugs in this class, including gentamicin, kanamycin, and tobramycin, you will not respond to edrophonium therapy. People who are allergic to shellfish or other medications containing epinephrine should not take edrophonium because an overdose could cause symptoms similar to those produced by epinephrine.
In conclusion, edrophonium is used as a test to see if someone is allergic to aminoglycosides. If you are going to use this drug, please read all instructions carefully before starting treatment.
Sodium calcium edetate (sodium calcium EDTA), also known as edetate calcium disodium and other names, is a drug used to treat lead poisoning, both short-term and long-term. It is also used as a preservative in vaccines.
EDTA is ethylenediaminetetraacetic acid. Its sodium salt is called sodium EDTA or simply edetate. Sodium calcium edetate is a white or off-white crystalline powder that dissolves in water to form a clear solution. The molecular weight of sodium calcium edetate is 447.9. It is practically insoluble in oil and soluble in alcohol, acetone, and ether.
Lead is a metal that can be found in many things including batteries, old paint, and some jewelry. Lead has harmful effects on your body if you are exposed to it for a long time. It can cause brain damage, behavioral problems, hearing loss, and kidney damage. Children are especially vulnerable to lead because their bodies are still developing so any exposure can have serious consequences.
If you are exposed to lead, doctors will often advise you to take supplements with EDTA in them. This helps remove the lead from your body. You should only take EDTA for a few weeks though, otherwise it will start removing essential minerals from your body, such as calcium and iron.
A battery of blood tests is done to check the function of your kidneys with an EDTA test. The name of the drug that you will be given via injection is EDTA. A tiny quantity of radioactive material is present in EDTA. This enables it to operate as a tracer, revealing kidney function. A second dose of non-radioactive EDTA is given one week later.
This test is used to find out if you are at risk for developing kidney problems over time. It can also help doctors identify any problem with your kidneys before it becomes serious enough to cause pain, illness or death.
Your doctor may suggest other tests if EDTA testing isn't sufficient for your needs. Other common tests include:
ACR - These tests measure the amount of protein in your urine. It is important to remember that even though you may have low levels of protein in your urine right now, this does not mean that you will always remain at this level. Your doctor may want to do more frequent tests to see how your protein levels change over time.
ALBUMIN - Albumin is a protein that is made by the body. Healthy adults usually have levels between 35 and 52 grams per L of blood. Lower levels indicate that you are at risk for developing kidney problems over time. Higher levels indicate that you have problems with your liver instead.
Enlon (edrophonium injection) should be delivered intravenously in 1 mL (10 mg) doses given slowly over a period of 30 to 45 seconds in order to identify the commencement of cholinergic response. This dosage can be repeated as needed. The usual total dose for an adult patient is 2 to 4 mg injected within 10 minutes of each other.
Edrophonium has been shown to be effective in preventing neuromuscular blockade caused by d-tubocurarine, pancuronium, and vecuronium. It may also be used in combination with atropine to reverse moderate to severe muscarinic poisoning from organophosphate compounds.
The drug is administered into a large vein, usually either the central vena cava or the internal jugular vein. It must be delivered rapidly after preparation in the syringe. A slow rate of delivery will result in no effect while a rapid rate will cause discomfort and pain at the site of injection.
Edrophonium has several advantages over neostigmine for the reversal of neuromuscular blockade: it does not require metabolic activation and its onset of action is faster than that of neostigmine.
It is available as a sterile solution for intravenous infusion. The concentration of edrophonium chloride in the solution is 40 mg/mL.
Patient Orientation Edrophonium is used to assist muscles recover from surgery. Atropine does not have the same negative effects as edrophonium, such as a sluggish pulse. Therefore, it is given before edrophonium to protect against cholinergic symptoms.
Muscle Relaxants Edrophonium is used to help relax muscles that are too tight. Atropine is used to reduce excessive sweating and tears in eyes caused by edrophonium. Atropine is also used to treat eye problems such as blurred vision, dry mouth, increased heart rate, and shortness of breath.
Atropine should be given no more than 30 minutes before or after edrophonium to avoid reducing the effectiveness of each drug. Starting both drugs at the same time may cause both to work too long and wear off too quickly.
Atropine is usually given by injection into a muscle once a day. It can be taken by mouth but this form of treatment is less effective. Atropine needs to be given under a doctor's care in a hospital setting because it can cause serious problems if you have an existing heart condition.